Can I run Molmo2-8B-Minimax-H3 on an RTX 5080?

Yes

Its published weights (9.29 GB) fit in the 14.4 GB an RTX 5080 can use, with room for ≈ 34K tokens of context.

hf download Alissonerdx/Molmo2-8B-Minimax-H3

Files and context on RTX 5080

Each file of Molmo2-8B-Minimax-H3 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

Molmo2-8B-Minimax-H3 on other hardware

Popular models that run on RTX 5080

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.