Can I run Underdog-Saluki-27B-1.0 on an RTX 4080?

Yes

Its Underdog-Saluki-27B-1.0-IQ2-mix file (7.90 GB) fits in the 14.4 GB an RTX 4080 can use, with room for ≈ 95K tokens of context.

ollama run hf.co/ConwayResearch/Underdog-Saluki-27B-1.0

Files and context on RTX 4080

Each file of Underdog-Saluki-27B-1.0 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

Underdog-Saluki-27B-1.0 on other hardware

Popular models that run on RTX 4080

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.