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Can I run Qwen3.8-40B-Ultimate-Heretic-Uncensored-Turbo-Brilliance-50x-AGI-NEO-GGUF on a Mac with 48 GB?

Yes, just

Its Q6_K file (32.4 GB) fits in the 36.0 GB a Mac with 48 GB can use, with room for ≈ 33K tokens of context.

Full analysis of Qwen3.8-40B-Ultimate-Heretic-Uncensored-Turbo-Brilliance-50x-AGI-NEO-GGUF Everything that runs on Mac with 48 GB Get the Q6_K file on Hugging Face
ollama run hf.co/DavidAU/Qwen3.8-40B-Ultimate-Heretic-Uncensored-Turbo-Brilliance-50x-AGI-NEO-GGUF:Q6_K

Files and context on Mac with 48 GB

Each file of Qwen3.8-40B-Ultimate-Heretic-Uncensored-Turbo-Brilliance-50x-AGI-NEO-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 48 GB Context (16-bit)Context (8-bit)
Q8_042.0 GBDoesn't fit——
Q6_K32.4 GBTight33K66K
Q5_K_M28.2 GBFits75K151K
Q5_K_S27.3 GBFits84K167K
Q4_K_M24.2 GBFits115K230K
Q4_K_S22.7 GBFits130K256K
Qwen3.8-40B-Ultimate-Heretic-Uncn-Turbo-Brilli-50x-AGI-NEO-MTP-IQ4_XS22.0 GBFits137K256K
IQ4_XS21.8 GBFits139K256K
IQ3_M18.3 GBFits173K256K
IQ2_M14.5 GBFits211K256K

Qwen3.8-40B-Ultimate-Heretic-Uncensored-Turbo-Brilliance-50x-AGI-NEO-GGUF on other hardware

Popular models that run on Mac with 48 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.