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Can I run Winnow-12B on a Mac with 512 GB?

Yes

Its Winnow-12B-BF16 file (23.8 GB) fits in the 384 GB a Mac with 512 GB can use, with room for ≈ 256K tokens of context.

Full analysis of Winnow-12B Everything that runs on Mac with 512 GB Get the Winnow-12B-BF16 file on Hugging Face
ollama run hf.co/EldanRing/Winnow-12B

Files and context on Mac with 512 GB

Each file of Winnow-12B (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 512 GB Context (16-bit)Context (8-bit)
Winnow-12B-BF1623.8 GBFits256K256K
Q8_012.7 GBFits256K256K
Winnow-12B-NVFP48.16 GBFits256K256K

Winnow-12B on other hardware

Popular models that run on Mac with 512 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.