Can I run POCKET-Darwin-180B-GGUF on a Mac with 512 GB?

Yes

Its UD-Q4_K_XL file (111 GB) fits in the 384 GB a Mac with 512 GB can use, with room for ≈ 256K tokens of context.

llama-server -hf FINAL-Bench/POCKET-Darwin-180B-GGUF:UD-Q4_K_XL

Files and context on Mac with 512 GB

Each file of POCKET-Darwin-180B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

POCKET-Darwin-180B-GGUF on other hardware

Popular models that run on Mac with 512 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.