Can I run GroundAnything-VLM on an RTX 5090?

Yes

Its published weights (9.69 GB) fit in the 28.8 GB an RTX 5090 can use, with room for ≈ 127K tokens of context.

Full analysis of GroundAnything-VLM Everything that runs on RTX 5090 Get the weights on Hugging Face

hf download GroundingPI/GroundAnything-VLM

Files and context on RTX 5090

Each file of GroundAnything-VLM (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On RTX 5090	Context (16-bit)	Context (8-bit)
As published	9.69 GB	Fits	127K	253K
4-bit (estimate)	2.72 GB	Fits	173K	256K

GroundAnything-VLM on other hardware

NVIDIA H100Yes
RTX 5090Yes
RTX 4090Yes
RTX 3090Yes
RTX 5060 Ti 16 GBYes
RTX 3060 12 GBYes, just
RTX 4060Probably, at 4-bit
Mac with 32 GBYes
Mac with 64 GBYes
Mac with 128 GBYes

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Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.