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Can I run K2-Horizon-7B-GGUF on an NVIDIA B300?

Yes

Its BF16 file (18.0 GB) fits in the 259 GB an NVIDIA B300 can use, with room for ≈ 512K tokens of context.

Full analysis of K2-Horizon-7B-GGUF Everything that runs on NVIDIA B300 Get the BF16 file on Hugging Face
ollama run hf.co/IFM/K2-Horizon-7B-GGUF:BF16

Files and context on NVIDIA B300

Each file of K2-Horizon-7B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn NVIDIA B300 Context (16-bit)Context (8-bit)
BF1618.0 GBFits512K512K
Q8_09.57 GBFits512K512K
Q6_K7.39 GBFits512K512K
Q5_K_M6.47 GBFits512K512K
Q5_06.34 GBFits512K512K
Q4_K_M5.59 GBFits512K512K

K2-Horizon-7B-GGUF on other hardware

Popular models that run on NVIDIA B300

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.