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Can I run Qwopus3.8-27B-Coder-Flash-GGUF on a Mac with 64 GB?

Yes

Its Q8_0 file (29.0 GB) fits in the 48.0 GB a Mac with 64 GB can use, with room for ≈ 256K tokens of context.

Full analysis of Qwopus3.8-27B-Coder-Flash-GGUF Everything that runs on Mac with 64 GB Get the Q8_0 file on Hugging Face
ollama run hf.co/Jackrong/Qwopus3.8-27B-Coder-Flash-GGUF:Q8_0

Files and context on Mac with 64 GB

Each file of Qwopus3.8-27B-Coder-Flash-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 64 GB Context (16-bit)Context (8-bit)
Q8_029.0 GBFits256K256K
Q6_K22.4 GBFits256K256K
Q5_K_M19.5 GBFits256K256K
Q4_K_M16.8 GBFits256K256K

Qwopus3.8-27B-Coder-Flash-GGUF on other hardware

Popular models that run on Mac with 64 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.