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Can I run Mellum2.1-12B-A2.5B-Thinking on a Mac with 96 GB?

Yes

Its published weights (24.3 GB) fit in the 72.0 GB a Mac with 96 GB can use, with room for ≈ 128K tokens of context.

Full analysis of Mellum2.1-12B-A2.5B-Thinking Everything that runs on Mac with 96 GB Get the weights on Hugging Face
hf download JetBrains/Mellum2.1-12B-A2.5B-Thinking

Files and context on Mac with 96 GB

Each file of Mellum2.1-12B-A2.5B-Thinking (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 96 GB Context (16-bit)Context (8-bit)
As published24.3 GBFits128K128K
Mellum2.1-12B-A2.5B-Thinking-MTP-BF16JetBrains/Mellum2.1-12B-A2.5B-Thinking-GGUF25.2 GBFits128K128K
BF16JetBrains/Mellum2.1-12B-A2.5B-Thinking-GGUF24.3 GBFits128K128K
Mellum2.1-12B-A2.5B-Thinking-MTP-Q8_0JetBrains/Mellum2.1-12B-A2.5B-Thinking-GGUF13.4 GBFits128K128K
Q8_0JetBrains/Mellum2.1-12B-A2.5B-Thinking-GGUF12.9 GBFits128K128K
Mellum2.1-12B-A2.5B-Thinking-MTP-Q6_KJetBrains/Mellum2.1-12B-A2.5B-Thinking-GGUF11.3 GBFits128K128K
Q6_KJetBrains/Mellum2.1-12B-A2.5B-Thinking-GGUF10.9 GBFits128K128K
Mellum2.1-12B-A2.5B-Thinking-MTP-Q4_K_MJetBrains/Mellum2.1-12B-A2.5B-Thinking-GGUF8.33 GBFits128K128K
Q4_K_MJetBrains/Mellum2.1-12B-A2.5B-Thinking-GGUF8.07 GBFits128K128K
Mellum2.1-12B-A2.5B-Thinking-MTP-MXFP4_MOEJetBrains/Mellum2.1-12B-A2.5B-Thinking-GGUF7.27 GBFits128K128K
MXFP4_MOEJetBrains/Mellum2.1-12B-A2.5B-Thinking-GGUF7.03 GBFits128K128K

Mellum2.1-12B-A2.5B-Thinking on other hardware

Popular models that run on Mac with 96 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.