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Can I run d1-omni-600M on an RTX 5080?

Yes

Its published weights (2.35 GB) fit in the 14.4 GB an RTX 5080 can use, with room for ≈ 125K tokens of context.

Full analysis of d1-omni-600M Everything that runs on RTX 5080 Get the weights on Hugging Face
hf download LiquidAI/d1-omni-600M

Files and context on RTX 5080

Each file of d1-omni-600M (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn RTX 5080 Context (16-bit)Context (8-bit)
As published2.35 GBFits125K125K
BF16LiquidAI/d1-omni-600M-GGUF764 MBFits125K125K
F16LiquidAI/d1-omni-600M-GGUF764 MBFits125K125K
Q8_0LiquidAI/d1-omni-600M-GGUF407 MBFits125K125K

d1-omni-600M on other hardware

Popular models that run on RTX 5080

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.