Can I run Qwen2.5-32B-Instruct-AWQ on a Mac with 64 GB?

Yes

Its published weights (19.3 GB) fit in the 48.0 GB a Mac with 64 GB can use, with room for ≈ 32K tokens of context.

Full analysis of Qwen2.5-32B-Instruct-AWQ Everything that runs on Mac with 64 GB Get the weights on Hugging Face

hf download Qwen/Qwen2.5-32B-Instruct-AWQ

Files and context on Mac with 64 GB

Each file of Qwen2.5-32B-Instruct-AWQ (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On Mac with 64 GB	Context (16-bit)	Context (8-bit)
As published	19.3 GB	Fits	32K	32K

Qwen2.5-32B-Instruct-AWQ on other hardware

NVIDIA H100Yes
RTX 5090Yes
RTX 4090Yes, just
RTX 3090Yes, just
RTX 5060 Ti 16 GBNo
RTX 3060 12 GBNo
RTX 4060No
Mac with 32 GBYes, just
Mac with 64 GBYes
Mac with 128 GBYes

Popular models that run on Mac with 64 GB

Qwen3-0.6BQwen · 752M
Qwen3-VL-8B-InstructQwen · 8.77B
gpt2openai-community · 137M
tiny-Qwen2ForCausalLM-2.5trl-internal-testing · 2.44M
Qwen3-8BQwen · 8.19B
Qwen3-Coder-30B-A3B-Instruct-GGUFunsloth · 30.5B
Qwen3.6-35B-A3B-FP8Qwen · 36.0B
Qwen2.5-7B-InstructQwen · 7.62B

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.