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Can I run Qwen3-14B-GGUF on an RTX 4080?

Yes, just

Its Q6_K file (12.1 GB) fits in the 14.4 GB an RTX 4080 can use, with room for ≈ 14K tokens of context.

Full analysis of Qwen3-14B-GGUF Everything that runs on RTX 4080 Get the Q6_K file on Hugging Face
ollama run hf.co/Qwen/Qwen3-14B-GGUF:Q6_K

Files and context on RTX 4080

Each file of Qwen3-14B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn RTX 4080 Context (16-bit)Context (8-bit)
Q8_015.7 GBDoesn't fit——
Q6_K12.1 GBTight14K27K
Q5_K_M10.5 GBFits23K40K
Q5_010.3 GBFits25K40K
Q4_K_M9.00 GBFits32K40K

Qwen3-14B-GGUF on other hardware

Popular models that run on RTX 4080

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.