Can I run Qwen3-235B-A22B-MLX-4bit on an RTX 4090?

Even its smallest file (As published, 125 GB) is more than an RTX 4090 can hold (21.6 GB usable): it needs 6 of them.

Full analysis of Qwen3-235B-A22B-MLX-4bit Everything that runs on RTX 4090

Files and context on RTX 4090

Each file of Qwen3-235B-A22B-MLX-4bit (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On RTX 4090	Context (16-bit)	Context (8-bit)
As published	125 GB	Doesn't fit	—	—

Qwen3-235B-A22B-MLX-4bit on other hardware

NVIDIA H100No
RTX 5090No
RTX 4090No
RTX 3090No
RTX 5060 Ti 16 GBNo
RTX 3060 12 GBNo
RTX 4060No
Mac with 32 GBNo
Mac with 64 GBNo
Mac with 128 GBNo

Popular models that run on RTX 4090

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Qwen2.5-7B-InstructQwen · 7.62B
Qwen3.5-9BQwen · 9.65B
Qwen2.5-0.5B-InstructQwen · 494M

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.