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Can I run Qwen3-4B-GGUF on an RTX 5090?

Yes

Its Q8_0 file (4.28 GB) fits in the 28.8 GB an RTX 5090 can use, with room for ≈ 40K tokens of context.

Full analysis of Qwen3-4B-GGUF Everything that runs on RTX 5090 Get the Q8_0 file on Hugging Face
ollama run hf.co/Qwen/Qwen3-4B-GGUF:Q8_0

Files and context on RTX 5090

Each file of Qwen3-4B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn RTX 5090 Context (16-bit)Context (8-bit)
Q8_04.28 GBFits40K40K
Q6_K3.31 GBFits40K40K
Q5_K_M2.89 GBFits40K40K
Q5_02.82 GBFits40K40K
Q4_K_M2.50 GBFits40K40K

Qwen3-4B-GGUF on other hardware

Popular models that run on RTX 5090

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.