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Can I run Qwen3-8B-MLX-4bit on a Radeon RX 7900 XTX?

Yes

Its published weights (4.35 GB) fit in the 21.6 GB a Radeon RX 7900 XTX can use, with room for ≈ 40K tokens of context.

Full analysis of Qwen3-8B-MLX-4bit Everything that runs on Radeon RX 7900 XTX Get the weights on Hugging Face
hf download Qwen/Qwen3-8B-MLX-4bit

Files and context on Radeon RX 7900 XTX

Each file of Qwen3-8B-MLX-4bit (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Radeon RX 7900 XTX Context (16-bit)Context (8-bit)
As published4.35 GBFits40K40K

Qwen3-8B-MLX-4bit on other hardware

Popular models that run on Radeon RX 7900 XTX

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.