Can I run Qwen3-Next-80B-A3B-Instruct-GGUF on an NVIDIA H200?

Yes

Its Q8_0 file (84.8 GB) fits in the 127 GB an NVIDIA H200 can use, with room for ≈ 256K tokens of context.

Full analysis of Qwen3-Next-80B-A3B-Instruct-GGUF Everything that runs on NVIDIA H200 Get the Q8_0 file on Hugging Face

ollama run hf.co/Qwen/Qwen3-Next-80B-A3B-Instruct-GGUF:Q8_0

Files and context on NVIDIA H200

Each file of Qwen3-Next-80B-A3B-Instruct-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On NVIDIA H200	Context (16-bit)	Context (8-bit)
Qwen3-Next-80B-A3B-Instruct	159 GB	Doesn't fit	—	—
Q8_0	84.8 GB	Fits	256K	256K
Q6_K	65.5 GB	Fits	256K	256K
Q5_K_M	56.7 GB	Fits	256K	256K
Q5_0	55.0 GB	Fits	256K	256K
Q4_K_M	48.4 GB	Fits	256K	256K

Qwen3-Next-80B-A3B-Instruct-GGUF on other hardware

Popular models that run on NVIDIA H200

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.