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Can I run Qwen3-VL-235B-A22B-Instruct-GGUF on a Mac with 512 GB?

Yes

Its Q8_0 file (250 GB) fits in the 384 GB a Mac with 512 GB can use, with room for ≈ 256K tokens of context.

Full analysis of Qwen3-VL-235B-A22B-Instruct-GGUF Everything that runs on Mac with 512 GB Get the Q8_0 file on Hugging Face
llama-server -hf Qwen/Qwen3-VL-235B-A22B-Instruct-GGUF:Q8_0

Files and context on Mac with 512 GB

Each file of Qwen3-VL-235B-A22B-Instruct-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 512 GB Context (16-bit)Context (8-bit)
F16470 GBDoesn't fit——
Q8_0250 GBFits256K256K
Q4_K_M142 GBFits256K256K

Qwen3-VL-235B-A22B-Instruct-GGUF on other hardware

Popular models that run on Mac with 512 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.