Can I run Qwen3-VL-2B-Instruct on an RTX 5060?

Yes

Its published weights (4.26 GB) fit in the 7.20 GB an RTX 5060 can use, with room for ≈ 25K tokens of context.

Full analysis of Qwen3-VL-2B-Instruct Everything that runs on RTX 5060 Get the weights on Hugging Face

hf download Qwen/Qwen3-VL-2B-Instruct

Files and context on RTX 5060

Each file of Qwen3-VL-2B-Instruct (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On RTX 5060	Context (16-bit)	Context (8-bit)
As published	4.26 GB	Fits	25K	50K
F16Qwen/Qwen3-VL-2B-Instruct-GGUF	3.45 GB	Fits	32K	64K
Q8_0Qwen/Qwen3-VL-2B-Instruct-GGUF	1.83 GB	Fits	46K	91K
Q4_K_MQwen/Qwen3-VL-2B-Instruct-GGUF	1.11 GB	Fits	52K	104K

Qwen3-VL-2B-Instruct on other hardware

Popular models that run on RTX 5060

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.