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Can I run Qwen3-VL-4B-Instruct-GGUF on an RTX 3090?

Yes

Its F16 file (8.05 GB) fits in the 21.6 GB an RTX 3090 can use, with room for ≈ 90K tokens of context.

Full analysis of Qwen3-VL-4B-Instruct-GGUF Everything that runs on RTX 3090 Get the F16 file on Hugging Face
ollama run hf.co/Qwen/Qwen3-VL-4B-Instruct-GGUF:F16

Files and context on RTX 3090

Each file of Qwen3-VL-4B-Instruct-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn RTX 3090 Context (16-bit)Context (8-bit)
F168.05 GBFits90K179K
Q8_04.28 GBFits115K229K
Q4_K_M2.50 GBFits127K253K

Qwen3-VL-4B-Instruct-GGUF on other hardware

Popular models that run on RTX 3090

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.