Can I run Qwen3.5-122B-A10B-FP8 on a Mac with 64 GB?

No

Even its smallest file (4-bit (estimate), 70.4 GB) is more than a Mac with 64 GB can hold (48.0 GB usable): it needs a Mac with 96 GB.

Files and context on Mac with 64 GB

Each file of Qwen3.5-122B-A10B-FP8 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

Qwen3.5-122B-A10B-FP8 on other hardware

Popular models that run on Mac with 64 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.