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Can I run Qwen3.5-27B-GPTQ-Int4 on a Mac with 48 GB?

Yes, just

Its published weights (30.2 GB) fit in the 36.0 GB a Mac with 48 GB can use, with room for ≈ 84K tokens of context.

Full analysis of Qwen3.5-27B-GPTQ-Int4 Everything that runs on Mac with 48 GB Get the weights on Hugging Face
hf download Qwen/Qwen3.5-27B-GPTQ-Int4

Files and context on Mac with 48 GB

Each file of Qwen3.5-27B-GPTQ-Int4 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 48 GB Context (16-bit)Context (8-bit)
As published30.2 GBTight84K167K
4-bit (estimate)15.6 GBFits256K256K

Qwen3.5-27B-GPTQ-Int4 on other hardware

Popular models that run on Mac with 48 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.