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Can I run Qwen3.5-397B-A17B-GPTQ-Int4 on an NVIDIA H100?

No

Even its smallest file (As published, 236 GB) is more than an NVIDIA H100 can hold (72.0 GB usable): it needs 4 of them.

Full analysis of Qwen3.5-397B-A17B-GPTQ-Int4 Everything that runs on NVIDIA H100

Files and context on NVIDIA H100

Each file of Qwen3.5-397B-A17B-GPTQ-Int4 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn NVIDIA H100 Context (16-bit)Context (8-bit)
As published236 GBDoesn't fit——

Qwen3.5-397B-A17B-GPTQ-Int4 on other hardware

Popular models that run on NVIDIA H100

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.