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Can I run Qwen3.8-27B on a Mac with 512 GB?

Yes

Its published weights (55.6 GB) fit in the 384 GB a Mac with 512 GB can use, with room for ≈ 256K tokens of context.

Full analysis of Qwen3.8-27B Everything that runs on Mac with 512 GB Get the weights on Hugging Face
hf download Qwen/Qwen3.8-27B

Files and context on Mac with 512 GB

Each file of Qwen3.8-27B (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 512 GB Context (16-bit)Context (8-bit)
As published55.6 GBFits256K256K
BF16ggml-org/Qwen3.8-27B-GGUF53.8 GBFits256K256K
Q8_0ggml-org/Qwen3.8-27B-GGUF28.6 GBFits256K256K
Q4_K_Mggml-org/Qwen3.8-27B-GGUF19.4 GBFits256K256K
BF16bartowski/Qwen3.8-27B-GGUF54.7 GBFits256K256K
Q8_0bartowski/Qwen3.8-27B-GGUF29.1 GBFits256K256K
Q6_K_Lbartowski/Qwen3.8-27B-GGUF25.0 GBFits256K256K
Q6_Kbartowski/Qwen3.8-27B-GGUF23.9 GBFits256K256K
Q6_K_Sbartowski/Qwen3.8-27B-GGUF22.9 GBFits256K256K
Q5_K_Lbartowski/Qwen3.8-27B-GGUF21.5 GBFits256K256K
Q5_K_Mbartowski/Qwen3.8-27B-GGUF20.9 GBFits256K256K
Q5_K_Sbartowski/Qwen3.8-27B-GGUF19.6 GBFits256K256K
Q4_K_Lbartowski/Qwen3.8-27B-GGUF18.8 GBFits256K256K
Q4_1bartowski/Qwen3.8-27B-GGUF17.8 GBFits256K256K
IQ4_NLbartowski/Qwen3.8-27B-GGUF17.4 GBFits256K256K
Q4_K_Mbartowski/Qwen3.8-27B-GGUF17.4 GBFits256K256K
Q3_K_XLbartowski/Qwen3.8-27B-GGUF16.4 GBFits256K256K
Q4_K_Sbartowski/Qwen3.8-27B-GGUF16.4 GBFits256K256K
Q4_0bartowski/Qwen3.8-27B-GGUF16.3 GBFits256K256K
IQ4_XSbartowski/Qwen3.8-27B-GGUF15.5 GBFits256K256K
IQ3_Mbartowski/Qwen3.8-27B-GGUF14.9 GBFits256K256K
Q3_K_Lbartowski/Qwen3.8-27B-GGUF14.1 GBFits256K256K
Q3_K_Mbartowski/Qwen3.8-27B-GGUF13.4 GBFits256K256K
Q2_K_Lbartowski/Qwen3.8-27B-GGUF13.1 GBFits256K256K
IQ3_XSbartowski/Qwen3.8-27B-GGUF12.8 GBFits256K256K
Q3_K_Sbartowski/Qwen3.8-27B-GGUF12.7 GBFits256K256K
IQ3_XXSbartowski/Qwen3.8-27B-GGUF12.3 GBFits256K256K
Q2_Kbartowski/Qwen3.8-27B-GGUF10.8 GBFits256K256K
IQ2_Mbartowski/Qwen3.8-27B-GGUF10.5 GBFits256K256K
IQ2_Sbartowski/Qwen3.8-27B-GGUF9.68 GBFits256K256K
IQ2_XSbartowski/Qwen3.8-27B-GGUF9.09 GBFits256K256K
IQ2_XXSbartowski/Qwen3.8-27B-GGUF8.88 GBFits256K256K
IQ4_XSbyteshape/Qwen3.8-27B-GGUF13.1 GBFits256K256K
IQ3_Sbyteshape/Qwen3.8-27B-GGUF11.0 GBFits256K256K
IQ3_XSbyteshape/Qwen3.8-27B-GGUF10.4 GBFits256K256K
IQ3_XXSbyteshape/Qwen3.8-27B-GGUF9.92 GBFits256K256K
IQ2_XXSbyteshape/Qwen3.8-27B-GGUF8.84 GBFits256K256K

Qwen3.8-27B on other hardware

Popular models that run on Mac with 512 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.