Can I run Kimi-K3-DSpark on an RTX 5090?

Yes

Its published weights (4.50 GB) fit in the 28.8 GB an RTX 5090 can use, with room for ≈ 1M tokens of context.

hf download RadixArk/Kimi-K3-DSpark

Files and context on RTX 5090

Each file of Kimi-K3-DSpark (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

Kimi-K3-DSpark on other hardware

Popular models that run on RTX 5090

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.