Can I run blip2-opt-2.7b on a Mac with 64 GB?

Yes

Its published weights (15.0 GB) fit in the 48.0 GB a Mac with 64 GB can use, with room for ≈ 98K tokens of context.

Full analysis of blip2-opt-2.7b Everything that runs on Mac with 64 GB Get the weights on Hugging Face

hf download Salesforce/blip2-opt-2.7b

Files and context on Mac with 64 GB

Each file of blip2-opt-2.7b (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On Mac with 64 GB	Context (16-bit)	Context (8-bit)
As published	15.0 GB	Fits	98K	197K
4-bit (estimate)	2.11 GB	Fits	137K	274K

blip2-opt-2.7b on other hardware

NVIDIA H100Yes
RTX 5090Yes
RTX 4090Yes
RTX 3090Yes
RTX 5060 Ti 16 GBProbably, at 4-bit
RTX 3060 12 GBProbably, at 4-bit
RTX 4060Probably, at 4-bit
Mac with 32 GBYes
Mac with 64 GBYes
Mac with 128 GBYes

Popular models that run on Mac with 64 GB

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Qwen3-8BQwen · 8.19B
Qwen3-Coder-30B-A3B-Instruct-GGUFunsloth · 30.5B
Qwen3.6-35B-A3B-FP8Qwen · 36.0B
Qwen2.5-7B-InstructQwen · 7.62B

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.