Can I run NeoHorse-1-4B on a Mac with 64 GB?

Yes

Its published weights (8.41 GB) fit in the 48.0 GB a Mac with 64 GB can use, with room for ≈ 256K tokens of context.

Full analysis of NeoHorse-1-4B Everything that runs on Mac with 64 GB Get the weights on Hugging Face

hf download TokenRhythm/NeoHorse-1-4B

Files and context on Mac with 64 GB

Each file of NeoHorse-1-4B (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On Mac with 64 GB	Context (16-bit)	Context (8-bit)
As published	8.41 GB	Fits	256K	256K
BF16TokenRhythm/NeoHorse-1-4B-GGUF	8.42 GB	Fits	256K	256K
F16TokenRhythm/NeoHorse-1-4B-GGUF	8.42 GB	Fits	256K	256K
Q8_0TokenRhythm/NeoHorse-1-4B-GGUF	4.48 GB	Fits	256K	256K
Q5_K_MTokenRhythm/NeoHorse-1-4B-GGUF	3.07 GB	Fits	256K	256K
Q4_K_MTokenRhythm/NeoHorse-1-4B-GGUF	2.71 GB	Fits	256K	256K

NeoHorse-1-4B on other hardware

Popular models that run on Mac with 64 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.