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Can I run Spark-X2.5-4B-GGUF on a Mac with 64 GB?

Yes

Its Spark-X2.5-4B file (8.23 GB) fits in the 48.0 GB a Mac with 64 GB can use, with room for ≈ 1M tokens of context.

Full analysis of Spark-X2.5-4B-GGUF Everything that runs on Mac with 64 GB Get the Spark-X2.5-4B file on Hugging Face
ollama run hf.co/XHToken/Spark-X2.5-4B-GGUF

Files and context on Mac with 64 GB

Each file of Spark-X2.5-4B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 64 GB Context (16-bit)Context (8-bit)
Spark-X2.5-4B8.23 GBFits1M1M
Q8_04.38 GBFits1M1M
Q4_K_M2.60 GBFits1M1M

Spark-X2.5-4B-GGUF on other hardware

Popular models that run on Mac with 64 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.