Can I run Spark-X2.5-4B on a Mac with 64 GB?

Yes

Its published weights (8.22 GB) fit in the 48.0 GB a Mac with 64 GB can use, with room for ≈ 1M tokens of context.

Full analysis of Spark-X2.5-4B Everything that runs on Mac with 64 GB Get the weights on Hugging Face

hf download XHToken/Spark-X2.5-4B

Files and context on Mac with 64 GB

Each file of Spark-X2.5-4B (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On Mac with 64 GB	Context (16-bit)	Context (8-bit)
As published	8.22 GB	Fits	1M	1M
Spark-X2.5-4BXHToken/Spark-X2.5-4B-GGUF	8.23 GB	Fits	1M	1M
Q8_0XHToken/Spark-X2.5-4B-GGUF	4.38 GB	Fits	1M	1M
Q4_K_MXHToken/Spark-X2.5-4B-GGUF	2.60 GB	Fits	1M	1M

Spark-X2.5-4B on other hardware

Popular models that run on Mac with 64 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.