Can I run Spark-X2.6-4B-Base on an NVIDIA B300?

Yes

Its published weights (8.22 GB) fit in the 259 GB an NVIDIA B300 can use, with room for ≈ 1M tokens of context.

hf download XHToken/Spark-X2.6-4B-Base

Files and context on NVIDIA B300

Each file of Spark-X2.6-4B-Base (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

Spark-X2.6-4B-Base on other hardware

Popular models that run on NVIDIA B300

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.