Can I run deepseek-v4-gguf on an RTX 4060?

No

Even its smallest file (DeepSeek-V4-Flash-IQ2XXS-w2Q2K-AProjQ8-SExpQ8-OutQ8-chat-v2, 86.7 GB) is more than an RTX 4060 can hold (7.20 GB usable): it needs more than 8 of them.

Files and context on RTX 4060

Each file of deepseek-v4-gguf (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

deepseek-v4-gguf on other hardware

Popular models that run on RTX 4060

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.