Can I run GLM-5.3-GGUF-DGX-Spark on an NVIDIA B300?

Yes

Its GLM-5.3-Q2-DGX-Spark file (161 GB) fits in the 259 GB an NVIDIA B300 can use, with room for ≈ 1M tokens of context.

llama-server -hf autotrust/GLM-5.3-GGUF-DGX-Spark

Files and context on NVIDIA B300

Each file of GLM-5.3-GGUF-DGX-Spark (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

GLM-5.3-GGUF-DGX-Spark on other hardware

Popular models that run on NVIDIA B300

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.