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Can I run GLM-5.3-GGUF-DGX-Spark on a Mac with 512 GB?

Yes

Its GLM-5.3-Q2-DGX-Spark file (161 GB) fits in the 384 GB a Mac with 512 GB can use, with room for ≈ 1M tokens of context.

Full analysis of GLM-5.3-GGUF-DGX-Spark Everything that runs on Mac with 512 GB Get the GLM-5.3-Q2-DGX-Spark file on Hugging Face
llama-server -hf autotrust/GLM-5.3-GGUF-DGX-Spark

Files and context on Mac with 512 GB

Each file of GLM-5.3-GGUF-DGX-Spark (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 512 GB Context (16-bit)Context (8-bit)
GLM-5.3-Q2-DGX-Spark161 GBFits1M1M

GLM-5.3-GGUF-DGX-Spark on other hardware

Popular models that run on Mac with 512 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.