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Can I run ERNIE-5.5-Flash-Base on a Mac with 512 GB?

Yes

Its published weights (288 GB) fit in the 384 GB a Mac with 512 GB can use, with room for ≈ 1M tokens of context.

Full analysis of ERNIE-5.5-Flash-Base Everything that runs on Mac with 512 GB Get the weights on Hugging Face
hf download baidu/ERNIE-5.5-Flash-Base

Files and context on Mac with 512 GB

Each file of ERNIE-5.5-Flash-Base (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 512 GB Context (16-bit)Context (8-bit)
As published288 GBFits1M1M
4-bit (estimate)161 GBFits1M1M

ERNIE-5.5-Flash-Base on other hardware

Popular models that run on Mac with 512 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.