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Can I run NousResearch_Arete-27B-GGUF on a Mac with 192 GB?

Yes

Its BF16 file (53.8 GB) fits in the 144 GB a Mac with 192 GB can use, with room for ≈ 256K tokens of context.

Full analysis of NousResearch_Arete-27B-GGUF Everything that runs on Mac with 192 GB Get the BF16 file on Hugging Face
llama-server -hf bartowski/NousResearch_Arete-27B-GGUF:BF16

Files and context on Mac with 192 GB

Each file of NousResearch_Arete-27B-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 192 GB Context (16-bit)Context (8-bit)
BF1653.8 GBFits256K256K
Q8_028.7 GBFits256K256K
Q6_K_L24.7 GBFits256K256K
Q6_K23.6 GBFits256K256K
Q6_K_S22.6 GBFits256K256K
Q5_K_M20.7 GBFits256K256K
Q5_K_S19.3 GBFits256K256K
Q4_K_L18.6 GBFits256K256K
Q4_117.6 GBFits256K256K
IQ4_NL17.2 GBFits256K256K
Q4_K_M17.2 GBFits256K256K
Q4_K_S16.1 GBFits256K256K
Q4_016.1 GBFits256K256K
IQ4_XS15.2 GBFits256K256K
IQ3_M14.6 GBFits256K256K
Q3_K_L13.9 GBFits256K256K
Q3_K_M13.2 GBFits256K256K
IQ3_XS12.6 GBFits256K256K
Q3_K_S12.5 GBFits256K256K
IQ3_XXS12.1 GBFits256K256K
Q2_K10.6 GBFits256K256K
IQ2_M10.3 GBFits256K256K
IQ2_S9.45 GBFits256K256K
IQ2_XS8.85 GBFits256K256K
IQ2_XXS8.64 GBFits256K256K

NousResearch_Arete-27B-GGUF on other hardware

Popular models that run on Mac with 192 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.