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Can I run Qwen3.8-27B-BaseQuant-V1 on an RTX 4060?

No

Even its smallest file (Qwen3.8-27B-BaseQuant-V1-XS, 8.36 GB) is more than an RTX 4060 can hold (7.20 GB usable): it needs 2 of them.

Full analysis of Qwen3.8-27B-BaseQuant-V1 Everything that runs on RTX 4060

Files and context on RTX 4060

Each file of Qwen3.8-27B-BaseQuant-V1 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn RTX 4060 Context (16-bit)Context (8-bit)
Qwen3.8-27B-BaseQuant-V1-XL25.3 GBDoesn't fit——
Qwen3.8-27B-BaseQuant-V1-Large20.8 GBDoesn't fit——
Qwen3.8-27B-BaseQuant-V1-Medium16.4 GBDoesn't fit——
Qwen3.8-27B-BaseQuant-V1-Small10.9 GBDoesn't fit——
Qwen3.8-27B-BaseQuant-V1-XS8.36 GBDoesn't fit——

Qwen3.8-27B-BaseQuant-V1 on other hardware

Popular models that run on RTX 4060

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.