Can I run DeepSeek-Coder-V2-Lite-Base on a Mac with 192 GB?

Yes

Its published weights (31.4 GB) fit in the 144 GB a Mac with 192 GB can use, with room for ≈ 160K tokens of context.

hf download deepseek-ai/DeepSeek-Coder-V2-Lite-Base

Files and context on Mac with 192 GB

Each file of DeepSeek-Coder-V2-Lite-Base (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

DeepSeek-Coder-V2-Lite-Base on other hardware

Popular models that run on Mac with 192 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.