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Can I run DeepSeek-V3 on a Mac with 128 GB?

No

Even its smallest file (4-bit (estimate), 385 GB) is more than a Mac with 128 GB can hold (96.0 GB usable): it needs more memory than any Mac has.

Full analysis of DeepSeek-V3 Everything that runs on Mac with 128 GB

Files and context on Mac with 128 GB

Each file of DeepSeek-V3 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 128 GB Context (16-bit)Context (8-bit)
As published689 GBDoesn't fit——
4-bit (estimate)385 GBDoesn't fit——

DeepSeek-V3 on other hardware

Popular models that run on Mac with 128 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.