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Can I run dots.ocr on a Mac with 48 GB?

Yes

Its published weights (6.08 GB) fit in the 36.0 GB a Mac with 48 GB can use, with room for ≈ 128K tokens of context.

Full analysis of dots.ocr Everything that runs on Mac with 48 GB Get the weights on Hugging Face
hf download dots-studio/dots.ocr

Files and context on Mac with 48 GB

Each file of dots.ocr (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 48 GB Context (16-bit)Context (8-bit)
As published6.08 GBFits128K128K
4-bit (estimate)1.71 GBFits128K128K

dots.ocr on other hardware

Popular models that run on Mac with 48 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.