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Can I run Qwen3.8-2B-Distill-GGUF on an RTX 5090?

Yes

Its BF16 file (3.90 GB) fits in the 28.8 GB an RTX 5090 can use, with room for ≈ 256K tokens of context.

Full analysis of Qwen3.8-2B-Distill-GGUF Everything that runs on RTX 5090 Get the BF16 file on Hugging Face
ollama run hf.co/empero-ai/Qwen3.8-2B-Distill-GGUF:BF16

Files and context on RTX 5090

Each file of Qwen3.8-2B-Distill-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn RTX 5090 Context (16-bit)Context (8-bit)
BF163.90 GBFits256K256K
Q8_02.08 GBFits256K256K
Q6_K1.61 GBFits256K256K
Q5_K_M1.45 GBFits256K256K
Q4_K_M1.31 GBFits256K256K

Qwen3.8-2B-Distill-GGUF on other hardware

Popular models that run on RTX 5090

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.