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Can I run Qwen3.8-35B-A3B-Distill on a Mac with 192 GB?

Yes

Its published weights (71.9 GB) fit in the 144 GB a Mac with 192 GB can use, with room for ≈ 256K tokens of context.

Full analysis of Qwen3.8-35B-A3B-Distill Everything that runs on Mac with 192 GB Get the weights on Hugging Face
hf download empero-ai/Qwen3.8-35B-A3B-Distill

Files and context on Mac with 192 GB

Each file of Qwen3.8-35B-A3B-Distill (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 192 GB Context (16-bit)Context (8-bit)
As published71.9 GBFits256K256K
BF16empero-ai/Qwen3.8-35B-A3B-Distill-GGUF71.1 GBFits256K256K
Q8_0empero-ai/Qwen3.8-35B-A3B-Distill-GGUF37.8 GBFits256K256K
Q6_Kempero-ai/Qwen3.8-35B-A3B-Distill-GGUF29.2 GBFits256K256K
Q5_K_Mempero-ai/Qwen3.8-35B-A3B-Distill-GGUF25.3 GBFits256K256K
Q4_K_Mempero-ai/Qwen3.8-35B-A3B-Distill-GGUF21.7 GBFits256K256K
IQ4_XSempero-ai/Qwen3.8-35B-A3B-Distill-GGUF19.6 GBFits256K256K
Q3_K_Mempero-ai/Qwen3.8-35B-A3B-Distill-GGUF17.7 GBFits256K256K
IQ3_Mempero-ai/Qwen3.8-35B-A3B-Distill-GGUF16.3 GBFits256K256K
Q2_Kempero-ai/Qwen3.8-35B-A3B-Distill-GGUF13.8 GBFits256K256K
IQ2_Mempero-ai/Qwen3.8-35B-A3B-Distill-GGUF12.6 GBFits256K256K

Qwen3.8-35B-A3B-Distill on other hardware

Popular models that run on Mac with 192 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.