Can I run GLiDE-27B on a Mac with 512 GB?

Yes

Its published weights (52.2 GB) fit in the 384 GB a Mac with 512 GB can use, with room for ≈ 256K tokens of context.

Full analysis of GLiDE-27B Everything that runs on Mac with 512 GB Get the weights on Hugging Face

hf download fastino/GLiDE-27B

Files and context on Mac with 512 GB

Each file of GLiDE-27B (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On Mac with 512 GB	Context (16-bit)	Context (8-bit)
As published	52.2 GB	Fits	256K	256K
4-bit (estimate)	14.7 GB	Fits	256K	256K

GLiDE-27B on other hardware

NVIDIA H100Yes
RTX 5090Probably, at 4-bit
RTX 4090Probably, at 4-bit
RTX 3090Probably, at 4-bit
RTX 5060 Ti 16 GBNo
RTX 3060 12 GBNo
RTX 4060No
Mac with 32 GBProbably, at 4-bit
Mac with 64 GBProbably, at 4-bit
Mac with 128 GBYes
Mac with 512 GBYes

Popular models that run on Mac with 512 GB

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Qwen3-VL-8B-InstructQwen · 8.77B
gpt2openai-community · 137M
Qwen3-8BQwen · 8.19B
Qwen3-Coder-30B-A3B-Instruct-GGUFunsloth · 30.5B
gemma-4-26B-A4B-itgoogle · 25.8B
Qwen2.5-7B-InstructQwen · 7.62B
Qwen3.5-9BQwen · 9.65B

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.