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Can I run Clef-Flash-GGUF on an RTX 4080?

Yes

Its Q8_0 file (9.66 GB) fits in the 14.4 GB an RTX 4080 can use, with room for ≈ 140K tokens of context.

Full analysis of Clef-Flash-GGUF Everything that runs on RTX 4080 Get the Q8_0 file on Hugging Face
ollama run hf.co/ggml-org/Clef-Flash-GGUF:Q8_0

Files and context on RTX 4080

Each file of Clef-Flash-GGUF (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn RTX 4080 Context (16-bit)Context (8-bit)
BF1618.2 GBDoesn't fit——
Q8_09.66 GBFits140K256K
Q4_K_M6.49 GBFits234K256K

Clef-Flash-GGUF on other hardware

Popular models that run on RTX 4080

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.