Can I run diffusiongemma-26B-A4B-it on a Mac with 256 GB?

Yes

Its published weights (51.6 GB) fit in the 192 GB a Mac with 256 GB can use, with room for ≈ 256K tokens of context.

Full analysis of diffusiongemma-26B-A4B-it Everything that runs on Mac with 256 GB Get the weights on Hugging Face

hf download google/diffusiongemma-26B-A4B-it

Files and context on Mac with 256 GB

Each file of diffusiongemma-26B-A4B-it (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On Mac with 256 GB	Context (16-bit)	Context (8-bit)
As published	51.6 GB	Fits	256K	256K
4-bit (estimate)	14.5 GB	Fits	256K	256K

diffusiongemma-26B-A4B-it on other hardware

NVIDIA H100Yes
RTX 5090Probably, at 4-bit
RTX 4090Probably, at 4-bit
RTX 3090Probably, at 4-bit
RTX 5060 Ti 16 GBNo
RTX 3060 12 GBNo
RTX 4060No
Mac with 32 GBProbably, at 4-bit
Mac with 64 GBProbably, at 4-bit
Mac with 128 GBYes
Mac with 256 GBYes

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Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.