Can I run h2o-lightning-4b on an RTX 5060 Ti 16 GB?

Yes

Its published weights (9.32 GB) fit in the 14.4 GB an RTX 5060 Ti 16 GB can use, with room for ≈ 150K tokens of context.

Full analysis of h2o-lightning-4b Everything that runs on RTX 5060 Ti 16 GB Get the weights on Hugging Face

hf download h2oai/h2o-lightning-4b

Files and context on RTX 5060 Ti 16 GB

Each file of h2o-lightning-4b (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On RTX 5060 Ti 16 GB	Context (16-bit)	Context (8-bit)
As published	9.32 GB	Fits	150K	256K
4-bit (estimate)	2.62 GB	Fits	256K	256K

h2o-lightning-4b on other hardware

NVIDIA H100Yes
RTX 5090Yes
RTX 4090Yes
RTX 3090Yes
RTX 5060 Ti 16 GBYes
RTX 3060 12 GBYes, just
RTX 4060Probably, at 4-bit
Mac with 32 GBYes
Mac with 64 GBYes
Mac with 128 GBYes

Popular models that run on RTX 5060 Ti 16 GB

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Qwen2.5-1.5B-InstructQwen · 1.54B
Qwen3-4BQwen · 4.02B
Qwen3.5-4BQwen · 4.66B
gpt-oss-20bopenai · 20.9B

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.