Can I run Qwen3.8-27B-MLX-5bit on an NVIDIA B300?

Yes

Its published weights (19.4 GB) fit in the 259 GB an NVIDIA B300 can use, with room for ≈ 256K tokens of context.

Full analysis of Qwen3.8-27B-MLX-5bit Everything that runs on NVIDIA B300 Get the weights on Hugging Face

hf download lmstudio-community/Qwen3.8-27B-MLX-5bit

Files and context on NVIDIA B300

Each file of Qwen3.8-27B-MLX-5bit (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On NVIDIA B300	Context (16-bit)	Context (8-bit)
As published	19.4 GB	Fits	256K	256K
4-bit (estimate)	15.4 GB	Fits	256K	256K

Qwen3.8-27B-MLX-5bit on other hardware

NVIDIA B300Yes
NVIDIA H100Yes
RTX 5090Yes
RTX 4090Yes, just
RTX 3090Yes, just
RTX 5060 Ti 16 GBNo
RTX 3060 12 GBNo
RTX 4060No
Mac with 32 GBYes, just
Mac with 64 GBYes
Mac with 128 GBYes

Popular models that run on NVIDIA B300

Qwen3-0.6BQwen · 752M
Qwen3-VL-8B-InstructQwen · 8.77B
gpt2openai-community · 137M
Qwen3-8BQwen · 8.19B
Qwen3-Coder-30B-A3B-Instruct-GGUFunsloth · 30.5B
gemma-4-26B-A4B-itgoogle · 25.8B
Qwen2.5-7B-InstructQwen · 7.62B
Qwen3.5-9BQwen · 9.65B

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.