Can I run Mage-VL-Cowork on an RTX 4080?

Yes

Its published weights (9.48 GB) fit in the 14.4 GB an RTX 4080 can use, with room for ≈ 33K tokens of context.

Full analysis of Mage-VL-Cowork Everything that runs on RTX 4080 Get the weights on Hugging Face

hf download microsoft/Mage-VL-Cowork

Files and context on RTX 4080

Each file of Mage-VL-Cowork (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On RTX 4080	Context (16-bit)	Context (8-bit)
As published	9.48 GB	Fits	33K	65K
4-bit (estimate)	2.67 GB	Fits	78K	155K

Mage-VL-Cowork on other hardware

NVIDIA H100Yes
RTX 5090Yes
RTX 4090Yes
RTX 3090Yes
RTX 4080Yes
RTX 5060 Ti 16 GBYes
RTX 3060 12 GBYes, just
RTX 4060Probably, at 4-bit
Mac with 32 GBYes
Mac with 64 GBYes
Mac with 128 GBYes

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Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.