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Can I run Phi-3.5-vision-instruct on a Mac with 32 GB?

Yes

Its published weights (8.29 GB) fit in the 21.3 GB a Mac with 32 GB can use, with room for ≈ 32K tokens of context.

Full analysis of Phi-3.5-vision-instruct Everything that runs on Mac with 32 GB Get the weights on Hugging Face
hf download microsoft/Phi-3.5-vision-instruct

Files and context on Mac with 32 GB

Each file of Phi-3.5-vision-instruct (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 32 GB Context (16-bit)Context (8-bit)
As published8.29 GBFits32K65K
4-bit (estimate)2.33 GBFits47K94K

Phi-3.5-vision-instruct on other hardware

Popular models that run on Mac with 32 GB

Assumes 67% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.