Can I run Kimi-Dev-72B on an NVIDIA B300?

Yes

Its published weights (145 GB) fit in the 259 GB an NVIDIA B300 can use, with room for ≈ 128K tokens of context.

Full analysis of Kimi-Dev-72B Everything that runs on NVIDIA B300 Get the weights on Hugging Face

hf download moonshotai/Kimi-Dev-72B

Files and context on NVIDIA B300

Each file of Kimi-Dev-72B (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

File	Size	On NVIDIA B300	Context (16-bit)	Context (8-bit)
As published	145 GB	Fits	128K	128K
4-bit (estimate)	40.9 GB	Fits	128K	128K

Kimi-Dev-72B on other hardware

NVIDIA B300Yes
NVIDIA H100Probably, at 4-bit
RTX 5090No
RTX 4090No
RTX 3090No
RTX 5060 Ti 16 GBNo
RTX 3060 12 GBNo
RTX 4060No
Mac with 32 GBNo
Mac with 64 GBProbably, at 4-bit
Mac with 128 GBProbably, at 4-bit

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Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.