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Can I run NVIDIA-Nemotron-Labs-Dory1.0-4B-BF16 on a Mac with 512 GB?

Yes

Its published weights (7.95 GB) fit in the 384 GB a Mac with 512 GB can use, with room for ≈ 256K tokens of context.

Full analysis of NVIDIA-Nemotron-Labs-Dory1.0-4B-BF16 Everything that runs on Mac with 512 GB Get the weights on Hugging Face
hf download nvidia/NVIDIA-Nemotron-Labs-Dory1.0-4B-BF16

Files and context on Mac with 512 GB

Each file of NVIDIA-Nemotron-Labs-Dory1.0-4B-BF16 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn Mac with 512 GB Context (16-bit)Context (8-bit)
As published7.95 GBFits256K256K
4-bit (estimate)2.24 GBFits256K256K

NVIDIA-Nemotron-Labs-Dory1.0-4B-BF16 on other hardware

Popular models that run on Mac with 512 GB

Assumes 75% of the Mac's memory is usable (macOS's default limit for the GPU; it can be raised) and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.