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Can I run MiniCPM-V-4.6 on an RTX 5090?

Yes

Its published weights (2.60 GB) fit in the 28.8 GB an RTX 5090 can use, with room for ≈ 256K tokens of context.

Full analysis of MiniCPM-V-4.6 Everything that runs on RTX 5090 Get the weights on Hugging Face
hf download openbmb/MiniCPM-V-4.6

Files and context on RTX 5090

Each file of MiniCPM-V-4.6 (and of GGUF versions the site has analyzed), and how much context fits next to it, with the context cache in 16-bit or 8-bit.

FileSizeOn RTX 5090 Context (16-bit)Context (8-bit)
As published2.60 GBFits256K256K
4-bit (estimate)731 MBFits256K256K

MiniCPM-V-4.6 on other hardware

Popular models that run on RTX 5090

Assumes 90% of the card's memory is usable and at least 4K tokens of context for one conversation, with the context cache in 16-bit unless noted. Fits leaves at least 20% of that memory for context; Tight leaves less.